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KMID : 0369819840140040189
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Jorunal of Korean Pharmaceutical Sciences
1984 Volume.14 No. 4 p.189 ~ p.194
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A Study on the Relative Bioavailability of Doxycycline Hyclate and Doxycycline - L methylenelysine
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김종갑:Kim Jong-Kab
최영욱:Choi Young-Wook
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Abstract
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The present study was undertaken to evaluate the relative bioavailability of doxycycline hyclate and doxycycline-L methylenelysine, a new synthetic derivative of doxycycline. Single doses, equivalent to 100㎎ of doxycycline hyclate, were administered orally to 10 healthy male volunteers.
Serum concentrations were determined periodically over 12 hrs by microbiological assay. Peak serum concentrations were reached within 4 hrs: doxycycline hyclate (1.38mcg·㎖^(-1)) gave 1.66 times higher concentration than that of doxycycline-L methylenelysine (0.83mcg·㎖^(-1)). And the areas under the serum concentration-time curves 0 to 12 hrs were 8.38mcg·hr·㎖^(-1) (doxycycline hyclate) and 5.56mcg·hr·㎖^(-1)(doxycycline-L methylenelysine).
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